IHP Post Doc Research Fellow | MGH Cancer Center
Postdoctoral Fellowship in Cancer Biology and TherapeuticsA postdoctoral fellowship position is available in the Miller laboratory at the Massachusetts General Hospital (MGH) Center for Cancer Research (CCR) and Harvard Medical School (HMS), located in Boston, MA.
Our laboratory studies clonal hematopoiesis and leukemia with a focus on understanding how somatic mutations arise in hematopoietic stem cells, contribute to the development of leukemia, and drive inflammatory phenotypes.
The ultimate goal of the laboratory is to develop new therapies to treat our patients.
We have a particular interest in the gene PPM1D, which is recurrently mutated in hematopoietic cells, most commonly after an individual has been exposed to chemotherapy or radiation.
We believe that understanding the context in which these mutations arise and their effects on stem cells will inform the broader mechanisms by which normal and leukemic cells respond to cellular and genotoxic stresses and highlight new therapeutic opportunities.
In separate but related work, we have also shown that clonal hematopoiesis of indeterminate potential (CHIP) is significantly associated with exposure to cigarette smoke and the presence of chronic obstructive inflammatory diseases and confirmed these findings in mouse models.
The Miller laboratory utilizes a range of techniques to develop and explore biological hypotheses, including human genetic analyses to define important associations grounded in human disease, mouse models to deeply interrogate the role of somatic alterations in hematopoiesis and leukemia, functional CRISPR/Cas9 genetic screening approaches, and molecular biology tools to define the mechanisms underlying the observed phenotypes.
We work in a highly collaborative fashion with cancer biologists, human geneticists, immunologists, chemists, and pulmonologists.
Our laboratory is in a research building on the main campus of MGH and is filled with world-leading labs across many disciplines with access to cutting edge research cores and technologies.
It is a demanding and fast-paced environment that requires hard work, attention to detail, and an ability to interact well with others as part of a cohesive team.
We are looking for highly motivated, experienced, and organized candidates with a PhD, MD, or MD/PhD.
The candidate must be well-versed in basic molecular biology and biochemical techniques.
Experience with mouse models is highly preferred and a willingness to work with mouse models is required.
The candidate must also have published their scientific work in the English-language literature.
The candidate will have the opportunity to work with others in the lab including with a technician.
Website:
https:
//www.
massgeneral.
org/cancer-center/clinical-trials-and-research/center-for-cancer-research/investigators/miller-lab />Specific Requirements Highly motivated and organized individual excited to work in a collaborative environment PhD, MD, or MD/PhD in biological sciences Well-versed in basic molecular biology and biochemical techniques including tissue culture, flow cytometry, bioinformatics Willingness to work with mouse models Prior publication of scientific work in English-language literature Postdoctoral Fellowship in Cancer Biology and TherapeuticsA postdoctoral fellowship position is available in the Miller laboratory at the Massachusetts General Hospital (MGH) Center for Cancer Research (CCR) and Harvard Medical School (HMS), located in Boston, MA.
Our laboratory studies clonal hematopoiesis and leukemia with a focus on understanding how somatic mutations arise in hematopoietic stem cells, contribute to the development of leukemia, and drive inflammatory phenotypes.
The ultimate goal of the laboratory is to develop new therapies to treat our patients.
We have a particular interest in the gene PPM1D, which is recurrently mutated in hematopoietic cells, most commonly after an individual has been exposed to chemotherapy or radiation.
We believe that understanding the context in which these mutations arise and their effects on stem cells will inform the broader mechanisms by which normal and leukemic cells respond to cellular and genotoxic stresses and highlight new therapeutic opportunities.
In separate but related work, we have also shown that clonal hematopoiesis of indeterminate potential (CHIP) is significantly associated with exposure to cigarette smoke and the presence of chronic obstructive inflammatory diseases and confirmed these findings in mouse models.
The Miller laboratory utilizes a range of techniques to develop and explore biological hypotheses, including human genetic analyses to define important associations grounded in human disease, mouse models to deeply interrogate the role of somatic alterations in hematopoiesis and leukemia, functional CRISPR/Cas9 genetic screening approaches, and molecular biology tools to define the mechanisms underlying the observed phenotypes.
We work in a highly collaborative fashion with cancer biologists, human geneticists, immunologists, chemists, and pulmonologists.
Our laboratory is in a research building on the main campus of MGH and is filled with world-leading labs across many disciplines with access to cutting edge research cores and technologies.
It is a demanding and fast-paced environment that requires hard work, attention to detail, and an ability to interact well with others as part of a cohesive team.
We are looking for highly motivated, experienced, and organized candidates with a PhD, MD, or MD/PhD.
The candidate must be well-versed in basic molecular biology and biochemical techniques.
Experience with mouse models is highly preferred and a willingness to work with mouse models is required.
The candidate must also have published their scientific work in the English-language literature.
The candidate will have the opportunity to work with others in the lab including with a technician.
Website:
https:
//www.
massgeneral.
org/cancer-center/clinical-trials-and-research/center-for-cancer-research/investigators/miller-lab />Specific Requirements Highly motivated and organized individual excited to work in a collaborative environment PhD, MD, or MD/PhD in biological sciences Well-versed in basic molecular biology and biochemical techniques including tissue culture, flow cytometry, bioinformatics Willingness to work with mouse models Prior publication of scientific work in English-language literature Massachusetts General Hospital is an Equal Opportunity Employer.
By embracing diverse skills, perspectives and ideas, we choose to lead.
Applications from protected veterans and individuals with disabilities are strongly encouraged.
Recommended Skills Attention To Detail Crispr Hardworking And Dedicated Molecular Biology Oncology Biochemistry Estimated Salary: $20 to $28 per hour based on qualifications.
Our laboratory studies clonal hematopoiesis and leukemia with a focus on understanding how somatic mutations arise in hematopoietic stem cells, contribute to the development of leukemia, and drive inflammatory phenotypes.
The ultimate goal of the laboratory is to develop new therapies to treat our patients.
We have a particular interest in the gene PPM1D, which is recurrently mutated in hematopoietic cells, most commonly after an individual has been exposed to chemotherapy or radiation.
We believe that understanding the context in which these mutations arise and their effects on stem cells will inform the broader mechanisms by which normal and leukemic cells respond to cellular and genotoxic stresses and highlight new therapeutic opportunities.
In separate but related work, we have also shown that clonal hematopoiesis of indeterminate potential (CHIP) is significantly associated with exposure to cigarette smoke and the presence of chronic obstructive inflammatory diseases and confirmed these findings in mouse models.
The Miller laboratory utilizes a range of techniques to develop and explore biological hypotheses, including human genetic analyses to define important associations grounded in human disease, mouse models to deeply interrogate the role of somatic alterations in hematopoiesis and leukemia, functional CRISPR/Cas9 genetic screening approaches, and molecular biology tools to define the mechanisms underlying the observed phenotypes.
We work in a highly collaborative fashion with cancer biologists, human geneticists, immunologists, chemists, and pulmonologists.
Our laboratory is in a research building on the main campus of MGH and is filled with world-leading labs across many disciplines with access to cutting edge research cores and technologies.
It is a demanding and fast-paced environment that requires hard work, attention to detail, and an ability to interact well with others as part of a cohesive team.
We are looking for highly motivated, experienced, and organized candidates with a PhD, MD, or MD/PhD.
The candidate must be well-versed in basic molecular biology and biochemical techniques.
Experience with mouse models is highly preferred and a willingness to work with mouse models is required.
The candidate must also have published their scientific work in the English-language literature.
The candidate will have the opportunity to work with others in the lab including with a technician.
Website:
https:
//www.
massgeneral.
org/cancer-center/clinical-trials-and-research/center-for-cancer-research/investigators/miller-lab />Specific Requirements Highly motivated and organized individual excited to work in a collaborative environment PhD, MD, or MD/PhD in biological sciences Well-versed in basic molecular biology and biochemical techniques including tissue culture, flow cytometry, bioinformatics Willingness to work with mouse models Prior publication of scientific work in English-language literature Postdoctoral Fellowship in Cancer Biology and TherapeuticsA postdoctoral fellowship position is available in the Miller laboratory at the Massachusetts General Hospital (MGH) Center for Cancer Research (CCR) and Harvard Medical School (HMS), located in Boston, MA.
Our laboratory studies clonal hematopoiesis and leukemia with a focus on understanding how somatic mutations arise in hematopoietic stem cells, contribute to the development of leukemia, and drive inflammatory phenotypes.
The ultimate goal of the laboratory is to develop new therapies to treat our patients.
We have a particular interest in the gene PPM1D, which is recurrently mutated in hematopoietic cells, most commonly after an individual has been exposed to chemotherapy or radiation.
We believe that understanding the context in which these mutations arise and their effects on stem cells will inform the broader mechanisms by which normal and leukemic cells respond to cellular and genotoxic stresses and highlight new therapeutic opportunities.
In separate but related work, we have also shown that clonal hematopoiesis of indeterminate potential (CHIP) is significantly associated with exposure to cigarette smoke and the presence of chronic obstructive inflammatory diseases and confirmed these findings in mouse models.
The Miller laboratory utilizes a range of techniques to develop and explore biological hypotheses, including human genetic analyses to define important associations grounded in human disease, mouse models to deeply interrogate the role of somatic alterations in hematopoiesis and leukemia, functional CRISPR/Cas9 genetic screening approaches, and molecular biology tools to define the mechanisms underlying the observed phenotypes.
We work in a highly collaborative fashion with cancer biologists, human geneticists, immunologists, chemists, and pulmonologists.
Our laboratory is in a research building on the main campus of MGH and is filled with world-leading labs across many disciplines with access to cutting edge research cores and technologies.
It is a demanding and fast-paced environment that requires hard work, attention to detail, and an ability to interact well with others as part of a cohesive team.
We are looking for highly motivated, experienced, and organized candidates with a PhD, MD, or MD/PhD.
The candidate must be well-versed in basic molecular biology and biochemical techniques.
Experience with mouse models is highly preferred and a willingness to work with mouse models is required.
The candidate must also have published their scientific work in the English-language literature.
The candidate will have the opportunity to work with others in the lab including with a technician.
Website:
https:
//www.
massgeneral.
org/cancer-center/clinical-trials-and-research/center-for-cancer-research/investigators/miller-lab />Specific Requirements Highly motivated and organized individual excited to work in a collaborative environment PhD, MD, or MD/PhD in biological sciences Well-versed in basic molecular biology and biochemical techniques including tissue culture, flow cytometry, bioinformatics Willingness to work with mouse models Prior publication of scientific work in English-language literature Massachusetts General Hospital is an Equal Opportunity Employer.
By embracing diverse skills, perspectives and ideas, we choose to lead.
Applications from protected veterans and individuals with disabilities are strongly encouraged.
Recommended Skills Attention To Detail Crispr Hardworking And Dedicated Molecular Biology Oncology Biochemistry Estimated Salary: $20 to $28 per hour based on qualifications.
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