Research Technologist
GENERAL SUMMARY/ OVERVIEW STATEMENT: .
Ongoing translational research in the Vincent Center for Reproductive Biology (VCRB) focuses on gynecologic cancers and benign conditions affecting fertility.
The Laboratory Technologist reports directly to the Director, Principal Investigator and/or managers of the laboratories and is expected to work independently on assigned research with minimal guidance from a higher level staff member or Principal Investigator. The ideal applicant is expected to have extensive experience in ovarian cancer research and is expected to lead a research project to study the etiology of ovarian high grade serous carcinoma using cellular and mouse models in a biomedical research laboratory. With broad guidance from the supervisor, the Technologist is expected to independently design and perform experiments to accomplish laboratory research goals. In addition, s/he will be responsible for documenting, analyzing, and reporting the results derived from cellular models, mouse models and/or patient samples. The Technologist will assist in the preparation of manuscripts for publication. The individual will also assist with gathering information needed for grant preparation and reporting and must be proficient in basic computer skills including word-processing, database and spreadsheet management, email and internet.
PRINCIPAL DUTIES AND
Responsibilities:
Primary responsibility of this role will be performing experiments in the biomedical research laboratory for NIH funded research, studying the etiology of gynecological cancers (mainly ovarian and cervical cancer) by creating transgenic mouse models, xenograft mouse models, and PDX mouse models. The applicant is also expected to be able to provide research support (e.g. transgenic animal handling and small animal surgery) for other researchers, including postdoctoral researchers and graduate students. In addition, the applicant is responsible for documenting, analyzing, and reporting the results associated with mouse model work. The Technologist will be expected to provide necessary research support for other researchers and assist the training of students, postdocs and fellows.
The primary responsibilities for this senior level research position are as follows:
Lead a research project to study the initiation and progression of ovarian high grade serous carcinoma using cellular and mouse models.
S/he is expected to design and conduct experiments independently in the laboratory with general guidance from the supervisor, and participate in the design of complex experiments.
Train junior researchers and technicians on techniques routinely used in the ovarian cancer etiology project. These techniques include, but are not limited to, DNA vector construction, viral packaging, fallopian tube secretory epithelial cell transfection, cell immortalization and cell line establishment, and two- and three-dimensional cell culture.
Generate required transgenic animals for the ovarian cancer etiology project. Design and conduct transgenic mouse model-associated experiments.
Perform routine surgeries on small experimental animals. Collect and analyze tissue samples from transgenic mice using histological, pathological and biochemical analyses.
Provide animal model-associated trainings (transgenic mouse colony maintenance, animal breeding, genotyping, small animal surgeries, etc.) for other researchers working on the ovarian etiology project.
Develop new experimental protocols, execute protocols of non-routine experiments, troubleshoot experimental problems and provide alternative approaches.
Independently collect and analyze experimental results using appropriate statistical analysis, judge the validity and reliability of experimental data, summarize research results, and prepare written progress reports.
Present research results at reginal, national or international scientific conferences.
Coordinate and collaborate with investigators in other laboratories to ensure success of ongoing or new projects. Work with scientists across a broad range of backgrounds.
Prepare data for grants and manuscripts.
Collects data and maintains records for animal breeding and maintenance
Complies with all the institutional rules and regulation on animal use and care.
Analyze animal model-associated experimental results, summarizes generated data, prepare PowerPoint Presentations.
Attend weekly lab meeting to conduct formal presentations of research methodology, findings and conclusions.
SKILLS/ABILITIES/COMPETENCIES REQUIRED:
The Technologist should have a strong background in cell biology, genetics, biochemistry and molecular biology and understand theories behind assays and procedures. Have the ability to identify problems and develop solutions.
The Technologist should be able to work independently and display initiative to introduce new methodologies to research study.
The Technologist should have comprehensive knowledge on experimental animal care and handling, especially handling and breeding transgenic mice for cancer research. Understands the physical, behavioral and environmental requirements of individual experimental animal species and be able to predict and interpret the animals' responses.
Ability to prepare IACUC and IRB protocols.
Ability to prioritize tasks and meet deadlines.
Sound interpersonal skills and the ability to train and supervise junior laboratory members.
Excellent oral and written communication skills.
PC and Mac competency is required
Knowledge of Microsoft Office, SPSS, statistical tools
Must be resourceful, self motivated, highly organized, have good time management skills, work cooperatively with others and be willing to learn new techniques
LICENSES, CERTIFICATIONS, and/or REGISTRATIONS (if applicable):
N/A
EDUCATION:
B.S. in Biology / Biomedical research training. Bachelor degree in Animal Science / Cancer research training preferred.
Experience:
3-5 years of experience and/or training in gynecological cancer research is required.
More than three years' experience in transgenic mouse model development is required. Extensive experiences in small animal husbandry and surgery are highly preferred.
Previous laboratory experience in cell culture, molecular biology, and histological studies is required.
SUPERVISORY RESPONSIBILITY (if applicable):
No direct reports. The Technologist will be expected to provide necessary research support for other researchers and assist the training of students, postdocs and fellows.
FISCAL RESPONSIBILITY (if applicable):
N/A
WORKING CONDITIONS:
Laboratory environment.
B.S. in Biology / Biomedical research training. Bachelor degree in Animal Science / Cancer research training preferred.
. Apply now!Estimated Salary: $20 to $28 per hour based on qualifications.
Ongoing translational research in the Vincent Center for Reproductive Biology (VCRB) focuses on gynecologic cancers and benign conditions affecting fertility.
The Laboratory Technologist reports directly to the Director, Principal Investigator and/or managers of the laboratories and is expected to work independently on assigned research with minimal guidance from a higher level staff member or Principal Investigator. The ideal applicant is expected to have extensive experience in ovarian cancer research and is expected to lead a research project to study the etiology of ovarian high grade serous carcinoma using cellular and mouse models in a biomedical research laboratory. With broad guidance from the supervisor, the Technologist is expected to independently design and perform experiments to accomplish laboratory research goals. In addition, s/he will be responsible for documenting, analyzing, and reporting the results derived from cellular models, mouse models and/or patient samples. The Technologist will assist in the preparation of manuscripts for publication. The individual will also assist with gathering information needed for grant preparation and reporting and must be proficient in basic computer skills including word-processing, database and spreadsheet management, email and internet.
PRINCIPAL DUTIES AND
Responsibilities:
Primary responsibility of this role will be performing experiments in the biomedical research laboratory for NIH funded research, studying the etiology of gynecological cancers (mainly ovarian and cervical cancer) by creating transgenic mouse models, xenograft mouse models, and PDX mouse models. The applicant is also expected to be able to provide research support (e.g. transgenic animal handling and small animal surgery) for other researchers, including postdoctoral researchers and graduate students. In addition, the applicant is responsible for documenting, analyzing, and reporting the results associated with mouse model work. The Technologist will be expected to provide necessary research support for other researchers and assist the training of students, postdocs and fellows.
The primary responsibilities for this senior level research position are as follows:
Lead a research project to study the initiation and progression of ovarian high grade serous carcinoma using cellular and mouse models.
S/he is expected to design and conduct experiments independently in the laboratory with general guidance from the supervisor, and participate in the design of complex experiments.
Train junior researchers and technicians on techniques routinely used in the ovarian cancer etiology project. These techniques include, but are not limited to, DNA vector construction, viral packaging, fallopian tube secretory epithelial cell transfection, cell immortalization and cell line establishment, and two- and three-dimensional cell culture.
Generate required transgenic animals for the ovarian cancer etiology project. Design and conduct transgenic mouse model-associated experiments.
Perform routine surgeries on small experimental animals. Collect and analyze tissue samples from transgenic mice using histological, pathological and biochemical analyses.
Provide animal model-associated trainings (transgenic mouse colony maintenance, animal breeding, genotyping, small animal surgeries, etc.) for other researchers working on the ovarian etiology project.
Develop new experimental protocols, execute protocols of non-routine experiments, troubleshoot experimental problems and provide alternative approaches.
Independently collect and analyze experimental results using appropriate statistical analysis, judge the validity and reliability of experimental data, summarize research results, and prepare written progress reports.
Present research results at reginal, national or international scientific conferences.
Coordinate and collaborate with investigators in other laboratories to ensure success of ongoing or new projects. Work with scientists across a broad range of backgrounds.
Prepare data for grants and manuscripts.
Collects data and maintains records for animal breeding and maintenance
Complies with all the institutional rules and regulation on animal use and care.
Analyze animal model-associated experimental results, summarizes generated data, prepare PowerPoint Presentations.
Attend weekly lab meeting to conduct formal presentations of research methodology, findings and conclusions.
SKILLS/ABILITIES/COMPETENCIES REQUIRED:
The Technologist should have a strong background in cell biology, genetics, biochemistry and molecular biology and understand theories behind assays and procedures. Have the ability to identify problems and develop solutions.
The Technologist should be able to work independently and display initiative to introduce new methodologies to research study.
The Technologist should have comprehensive knowledge on experimental animal care and handling, especially handling and breeding transgenic mice for cancer research. Understands the physical, behavioral and environmental requirements of individual experimental animal species and be able to predict and interpret the animals' responses.
Ability to prepare IACUC and IRB protocols.
Ability to prioritize tasks and meet deadlines.
Sound interpersonal skills and the ability to train and supervise junior laboratory members.
Excellent oral and written communication skills.
PC and Mac competency is required
Knowledge of Microsoft Office, SPSS, statistical tools
Must be resourceful, self motivated, highly organized, have good time management skills, work cooperatively with others and be willing to learn new techniques
LICENSES, CERTIFICATIONS, and/or REGISTRATIONS (if applicable):
N/A
EDUCATION:
B.S. in Biology / Biomedical research training. Bachelor degree in Animal Science / Cancer research training preferred.
Experience:
3-5 years of experience and/or training in gynecological cancer research is required.
More than three years' experience in transgenic mouse model development is required. Extensive experiences in small animal husbandry and surgery are highly preferred.
Previous laboratory experience in cell culture, molecular biology, and histological studies is required.
SUPERVISORY RESPONSIBILITY (if applicable):
No direct reports. The Technologist will be expected to provide necessary research support for other researchers and assist the training of students, postdocs and fellows.
FISCAL RESPONSIBILITY (if applicable):
N/A
WORKING CONDITIONS:
Laboratory environment.
B.S. in Biology / Biomedical research training. Bachelor degree in Animal Science / Cancer research training preferred.
. Apply now!Estimated Salary: $20 to $28 per hour based on qualifications.
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